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Research Articles Analyses
Name
Institutional Affiliation
Course Code and Title
Instructor’s Name
Due Date
Appendix A
Citation
Question or
Hypothesis
Theoretical
Foundation
Yousefzadeh et
al., 2021
An aged immune
system drives
systemic changes
associated with
normal ageing
Empirical
framework
Granic et al.,
2022
Very old adults
(aged ≥85 years)
live with multiple
Empirical
framework
Research Design
(include tools)
and Sample Size
Mice were
randomly
assigned to
experimental
groups except for
experiments
requiring
specified
genotypes and
ages. During
experiments and
outcome
evaluation, the
investigators had
no access to the
allocation, except
in a few unusual
situations when
blinding was not
practicable.
Sample size: 30
Tool: The Helios
CyTOF system
Sample: 703
Tool: SPSS
Software
Key Findings
Recommendatio
ns/
Implications
An aged,
Further research
senescent
should be
immune system is conducted to
causal in driving
investigate how
systemic aging
period of
and represents a
morbidity in old
key therapeutic
age can be
target to extend
compressed.
healthy aging.
In the analytic
sample only 6.8%
participants had 2
Further studies
should determine
whether
Level of
Evidence
Level II
Level II
long-term
conditions
(MLTC) or
multimorbidity—
a complex
phenomenon of
poor health
defined by either
counts (≥2
diseases), indices,
or patterns.
Wilson et al.,
2019
Lonelier people
Empirical
have more severe framework
sympathetic
responses to acute
stress, increasing

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