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Neocortical Morphometry in Huntington’s Disease Discussion
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August 12, 2023
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Discussion – Neocortical Morphometry in Huntington’s Disease
Mangin et al. (2020) delve deeply into the complex topography of neocortical
morphometry in Huntington’s disease (HD). Through extensive studies, the researchers have
effectively highlighted the previously unknown cohabitation of abnormal
“neurodevelopmental and neurodegenerative” processes in the early stages of the disease. The
inventive use of sulcal morphometry analysis, and rigorous research that encompasses both
the nuanced depths and interesting lengths of specific brain sulci, distinguishes this
investigation. While HD, a dominant autosomal illness, has traditionally been classified as a
neurodegenerative disorder, this work boldly delves into the unknown domain of potential
effects on normal brain development, introducing a fundamental paradigm change (Mangin et
al., 2020). The use of sulcal morphometry, a method not previously employed in this context,
to explore the interaction of neurodevelopmental and neurodegenerative processes in HD is a
significant novelty. The findings explore the idea that HD is predominantly a degenerative
question, revealing significant changes in sulcal depth, particularly in the central and intraparietal sulci. Furthermore, in HD patients, the left posterior Sylvian fissure was shorter, and
asymmetry was absent, indicating early damage to ne …
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